THE NEUROPSYCHIATRY OF SCHIZOPHRENIA AND THE OUTCOME OF PHARMACOLOGICAL MANAGEMENT

Amanda Hatsue Santana Endo, Marília Sonda, Leila Andrade da Silva,

Flávia de Albuquerque Leão Costa, Samantha Santos Veloso, Maria Fernanda Athayde

Vasconcelos de Toledo, Isabelle Marques Mendes, Emily Alencar Silva, Lucas Bastos Faria,

Gustavo Snidarcis Berti, Izabella Manso Heinzen,Juliana Gioia Negrão, Andressa Rafaella

Rodrigues de Moura, Breno Nunes Feitosa, Matheus Ruiz de Faria, João Victor Costa Barreto

Brígido, Renner Pereira da Silva Melo, Mariana Abucater Couto, Ricardo Cavalari Dória,

Gabriella Beltrame Pintos, Isadora Hoff Mouawad, Francisco José Pascoal Ribeiro Junior,

Vinicius Teixeira Ferreira Capel, Kelly Ribeiro Moura Barboza, Nildo Redivo Junior, Maria

Lorena Ribeiro Redivo, Joaquim Ponciano Gonçalves Pereira, Waleska Palhares Pires,

Gabriela Bom Colás, Dalmo Hollen Dias Aniceto de Lima, Myrna Maria Costa de Melo

Silveira, Marina Maria Alencar Pinto Rocha, Arthur Cezar Schmidt, Gabriel Rozendo

Mendonça Gomes, Francisco Eliezer Curado A, Denise Cristina Pacheco, Nicole Martins de

Freitas Cintra, Marcelo Jorge Machado Nazareth, Alex Carlos Souza Silva, Gabriel Souza

Brito da Silva, Lorena Lis Nolêto Sá Corrêa, Erica Kroeff Piva, Marina de Jesus Almeida da

Silva, Maria Paula Pereira Gerlach, Edlon Luiz Lamounier Júnior, Bruna Mansano Estigarribia,

Roberto Carlos Rivero Salazar, Lorena Pereira Bidá, José Mateus Rabelo Diniz Sampaio,

Edna Carla Epifânio de Oliveira , João Vitor Rincon Siqueira , Gabriela Fernanda Dini de

Freitas , Antonio Luiz Vieira Gonçalves , João Dorival Lucas da Costa Filho , Romulo

Gonçalves de Moura Lucena , Bernardo Rivera Fernandes Severo, Felipe Lacerda de Oliveira

Abrahão , Daniel Garcia Pimenta , Gabriel Pires de Pádua, Aymê Fuzi Kawagoe , Samira

Almeida Estrela de Oliveira, Cássia Marina de Oliveira Santana, Mariana Monteiro Resende,

Larissa Strutz Salviato.

Abstract

Schizophrenia is a type of psychosis accompanied by positive symptoms (hallucinations, delusions) and/or negative symptoms (apathy, indifference). Mostly, it begins in adolescence or early adulthood, affecting about 1% of the population, being potentially chronic and disabling. These do not have a specific causal factor, but a genetic influence along with an essential biochemical abnormality, possibly a dysfunction of mesolimbic or mesocortical dopaminergic neuronal pathways, is acceptable. The psychotic complex is based on distortion of reality and misappropriation of affect. The most relevant psychopathological events include delusions, hallucinations, incomprehensible speech and socio-occupational impairment. However, clear consciousness and intellectual aptitude are preserved, although cognitive impairment may occur over time. Cognitive alterations are extensive and are the focus of attention both in identification and in rehabilitation, considering that they generate considerable suffering for patients and those who live with them.

Keywords: Schizophrenia, Cognition, Delusions, Antipsychotics, Catatonia